The ITGA2B Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CD41, CD41b, GpIIb, HPA3, integrin, alpha 2b, and ITGA2B. This antibody recognizes Human, Mouse, and Rat antigen. The ITGA2B Polyclonal Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling